Carbene-catalyzed direct O-functionalization of ketone: atroposelective access to non-C₂-symmetric binaphthyls

Carbene-catalyzed direct O-functionalization of ketone: atroposelective access to non-C₂-symmetric binaphthyls

Disclosed here is NHC-catalyzed direct intermolecular trapping of the ketone oxygen atom with the acyl azolium intermediate. The overall reaction is a dynamic kinetic resolution process that converts ketone to the corresponding enol ester with well-controlled axial chirality. Our reaction eventually...

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Bibliographic Details
Main Authors: Mondal, Bivas, Chen, Hang, Maiti, Rakesh, Wang, Hongling, Cai, Hui, Mou, Chengli, Hao, Lin, Chai, Huifang, Chi, Robin Yonggui
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Journal Article
Language:English
Published: 2024
Subjects:
Chemistry
Ketone
Atroposelective Access
Online Access:https://hdl.handle.net/10356/173356

Internet

https://hdl.handle.net/10356/173356

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