Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian...

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Bibliographic Details
Main Authors: Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J., Ross, Leila S., Ward, Kurt E., Dhingra, Satish K., Kanai, Mariko, Bridgford, Jessica L., Tripathi, Abhai K., Mlambo, Godfree, Burkhard, Anna Y., Ansbro, Megan R., Fairhurst, Kate J., Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D., Kim, Jonathan, Mancia, Filippo, Fairhurst, Rick M., Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Drug resistance
Genetics
Online Access:https://hdl.handle.net/10356/173815

Internet

https://hdl.handle.net/10356/173815

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