High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo

High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo

The F1FO-ATP synthase engine is essential for viability and growth of nontuberculous mycobacteria (NTM) by providing the biological energy ATP and keeping ATP homeostasis under hypoxic stress conditions. Here, we report the discovery of the diarylquinoline TBAJ-5307 as a broad spectrum anti-NTM...

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Detalhes bibliográficos
Principais autores: Ragunathan, Priya, Sae-Lao, Patcharaporn, Hamela, Claire, Alcaraz, Matthéo, Krah, Alexander, Poh, Wee Han, Pee, Carmen Jia Ern, Lim, Albert Yick Hou, Rice, Scott A., Pethe, Kevin, Bond, Peter J., Dick, Thomas, Kremer, Laurent, Bates, Roderick Wayland, Grüber, Gerhard
Outros Autores: School of Biological Sciences
Formato: Journal Article
Idioma:English
Publicado em: 2024
Assuntos:
Medicine, Health and Life Sciences
Mycobacteria
Nontuberculosis mycobacterium
Acesso em linha:https://hdl.handle.net/10356/175508

Internet

https://hdl.handle.net/10356/175508

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