High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo

High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo

The F1FO-ATP synthase engine is essential for viability and growth of nontuberculous mycobacteria (NTM) by providing the biological energy ATP and keeping ATP homeostasis under hypoxic stress conditions. Here, we report the discovery of the diarylquinoline TBAJ-5307 as a broad spectrum anti-NTM...

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Bibliographic Details
Main Authors: Ragunathan, Priya, Sae-Lao, Patcharaporn, Hamela, Claire, Alcaraz, Matthéo, Krah, Alexander, Poh, Wee Han, Pee, Carmen Jia Ern, Lim, Albert Yick Hou, Rice, Scott A., Pethe, Kevin, Bond, Peter J., Dick, Thomas, Kremer, Laurent, Bates, Roderick Wayland, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Mycobacteria
Nontuberculosis mycobacterium
Online Access:https://hdl.handle.net/10356/175508

Internet

https://hdl.handle.net/10356/175508

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