Nontoxic, biodegradable hyperbranched poly(β-amino ester)s for efficient siRNA delivery and gene silencing

Nontoxic, biodegradable hyperbranched poly(β-amino ester)s for efficient siRNA delivery and gene silencing

RNA interference (RNAi)-mediated gene silencing is a promising therapeutic approach to treat various diseases, but safe and efficient delivery remains a major challenge to its clinical application. Non-viral gene vectors, such as poly(β-amino esters) (pBAEs), have emerged as a potential candidate du...

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Bibliographic Details
Main Authors: Ooi, Ying Jie, Huang, Chongquan, Lau, Kieran, Chew, Sing Yian, Park, Jong Gu, Chan-Park, Mary B.
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Gene silencing
Primary neural cells
Online Access:https://hdl.handle.net/10356/176048

Internet

https://hdl.handle.net/10356/176048

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