Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome

Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome

Nigericin, an ionophore derived from Streptomyces hygroscopicus, is arguably the most commonly used tool compound to study the NLRP3 inflammasome. Recent findings, however, showed that nigericin also activates the NLRP1 inflammasome in human keratinocytes. In this study, we resolve the mechanistic b...

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Bibliographic Details
Main Authors: Rozario, Pritisha, Pinilla, Miriam, Gorse, Leana, Vind, Anna Constance, Robinson, Kim S., Toh, Gee Ann, Muhammad Jasrie Firdaus, Martínez, José Francisco, Kerk, Swat Kim, Lin, Zhewang, Chambers, John Campbell, Bekker-Jensen, Simon, Meunier, Etienne, Zhong, Franklin
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Autophosphorylation
Bright field microscopy
Online Access:https://hdl.handle.net/10356/176261

Internet

https://hdl.handle.net/10356/176261

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