Tumor phylogeography reveals block-shaped spatial heterogeneity and the mode of evolution in hepatocellular carcinoma

Tumor phylogeography reveals block-shaped spatial heterogeneity and the mode of evolution in hepatocellular carcinoma

Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-tumor heterogeneity (sITH) at the macroscopic (i.e., whole tumor) level is under-explored. Using a phylogeographic approach, we sequence genomes and transcriptomes from 235 spatially informed sectors across 1...

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Bibliographic Details
Main Authors: Liu, Xiaodong, Zhang, Ke, Kaya, Neslihan A., Jia, Zhe, Wu, Dafei, Chen, Tingting, Liu, Zhiyuan, Zhu, Sinan, Hillmer, Axel M., Wuestefeld, Torsten, Liu, Jin, Chan, Yun Shen, Hu, Zheng, Ma, Liang, Jiang, Li, Zhai, Weiwei
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Phylogeography
Liver cell carcinoma
Online Access:https://hdl.handle.net/10356/179589

Internet

https://hdl.handle.net/10356/179589

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