Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy

Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is typically characterized as a motor neuron disease, but extra-neuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extra-neuronal phenotypes were previously underappreciated as patients with severe SMA phenotypes usual...

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Bibliographic Details
Main Authors: Leow, Damien Meng-Kiat, Ng, Yang Kai, Wang, Loo Chien, Koh, Hiromi W. L., Zhao, Tianyun, Khong, Zi Jian, Tabaglio, Tommaso, Narayanan, Gunaseelan, Giadone, Richard M., Sobota, Radoslaw M., Ng, Shi-Yan, Teo, Adrian Kee Keong, Parson, Simon H., Rubin, Lee L., Ong, Wei-Yi, Darras, Basil T., Yeo, Crystal Jing Jing
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Fatty liver
Spinal muscular atrophy
Online Access:https://hdl.handle.net/10356/179711

Internet

https://hdl.handle.net/10356/179711

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