Disentangling oncogenic amplicons in esophageal adenocarcinoma

Disentangling oncogenic amplicons in esophageal adenocarcinoma

Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal adenocarcinoma cases w...

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Bibliographic Details
Main Authors: Ng, Alvin Wei Tian, McClurg, Dylan Peter, Wesley, Ben, Zamani, Shahriar A., Black, Emily, Miremadi, Ahmad, Giger, Olivier, Hoopen, Rogier Ten, Devonshire, Ginny, Redmond, Aisling M., Grehan, Nicola, Jammula, Sriganesh, Blasko, Adrienn, Li, Xiaodun, Aparicio, Samuel, Tavaré, Simon, Nowicki-Osuch, Karol, Fitzgerald, Rebecca C.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Adenocarcinoma
Clonal evolution
Online Access:https://hdl.handle.net/10356/179745

Internet

https://hdl.handle.net/10356/179745

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