Disentangling oncogenic amplicons in esophageal adenocarcinoma
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal adenocarcinoma cases w...
Main Authors: | Ng, Alvin Wei Tian, McClurg, Dylan Peter, Wesley, Ben, Zamani, Shahriar A., Black, Emily, Miremadi, Ahmad, Giger, Olivier, Hoopen, Rogier Ten, Devonshire, Ginny, Redmond, Aisling M., Grehan, Nicola, Jammula, Sriganesh, Blasko, Adrienn, Li, Xiaodun, Aparicio, Samuel, Tavaré, Simon, Nowicki-Osuch, Karol, Fitzgerald, Rebecca C. |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2024
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/179745 |
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