Structural and mutagenesis studies of the NS3 helicase from dengue virus for drug discovery
With reference to the structure analysis of RNA unwinding mechanism coupled with ATP hydrolysis by Dengue virus (DEN) non-structural 3 (NS3) protein (Luo et al., 2008a), site-directed mutagenesis on DEN NS3 helicase domain was performed. Five residues conserved among Flaviviridae were selected for m...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/10356/18935 |