IGF-1 stimulation via GSK-3β and screening for genes conferring protection of SHEP-1 cells against MPP+ toxicity
1-methyl-4-phenylpyridinium (MPP+) causes Parkinsonism and has been widely used in experimental models of Parkinson’s disease. MPP+ was used to induce apoptosis in human dopaminergic neural SHEP-1 cells in order to identify and characterise genes that may protect against MPP+ toxicity. In this stud...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/10356/19313 |