Iron-catalyzed α-amidation of heterocycles with potential route to amino alcohols, amino thiols, and diamino products by nucleophilic ring opening.
An efficient method for α-amidation of heterocyclic moieties via direct nitrene insertion catalyzed by iron(III)trifluoromethanesulfonate with PhI=NTs (Ts = p-toluenesulfonyl)as a nitrogen source is reported herein. This reaction was shown to be applicable to cyclic ethers, cyclic thioethers, and py...
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| 格式: | Final Year Project (FYP) |
| 语言: | English |
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2010
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| 在线阅读: | http://hdl.handle.net/10356/39888 |