Gold catalyzed intramolecular cyclization of (2-aminophenyl)-cyclopropyl methanols as an expedient route to 2,3-dihydro-1h-benzazepines and indolines.
We reported herein an efficient synthetic route of 2,3-dihydro-1H-benzazepines and indolines that relies on (4-CF3Ph)3PAuCl/AgOTf catalyzed intramolecular hydroamination of cyclopropyl methanols containing an aniline moiety. The methodology is applicable to a wide range of electron-donating, elec...
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Format: | Final Year Project (FYP) |
Language: | English |
Published: |
2010
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Online Access: | http://hdl.handle.net/10356/39933 |