Synthesis of substituted pyrrolo- and indolo-quinoxalines via the gold(i)-catalyzed tandem hydroamination-hydroarylation of pyrrole- and indole-substituted anilines with aromatic terminal alkynes.
A concise, asymmetric synthesis of substituted 3-pyrrolines from the corresponding amino-homoallylic alcohols derived from amino acids is described. The key step is an intramolecular hydroamination reaction catalyzed by copper(II) triflate. The 3-pyrroline products were obtained in moderate to good...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/40106 |