A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis
Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In...
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| Format: | Thesis |
| Language: | English |
| Published: |
2012
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| Online Access: | https://hdl.handle.net/10356/50212 |