Biophysical and structural studies of aggregation of nucleosome core particle with charge modified histone proteins.
The core histone proteins H2A, H2B, H3 and H4 constitute the spool for the DNA hierarchical packaging in eukaryotes and form the basic chromatin structural unit of the nucleosome core particle (NCP). The positive charges on the histone H4 N-terminal tails extensively interact with DNA through electr...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://hdl.handle.net/10356/50715 |