Exploring the limits of solution-state NMR in application to challenging proteins in drug discovery
Solution state Nuclear Magnetic Resonance Spectroscopy, despite its emergence as an important technique has its own limits: rapid transverse relaxation proportional to the molecular size of the protein, slow longitudinal relaxation and resonance overlap with increasing molecular size. While the limi...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | https://hdl.handle.net/10356/50874 |