Generation of female fibroblast cell lines in which Xist is conditionally and allele-specifically deleted from the inactive X chromosome.
Dosage compensation is accomplished by X chromosome inactivation (XCI) in female cells of placental mammals. The silencing of either the paternal or the maternal X chromosome ensures the equal expression of X-linked genes in males and females. Xist is a critical gene involved in regulating XCI. The...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2012
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| Online Access: | http://hdl.handle.net/10356/50882 |