Structural and functional studies of enzymes from the enediyne polyketide biosynthetic pathway
Enediyne polyketides are extremely potent antitumor antibiotics with a remarkable core structure consisting of two acetylenic group conjugated to a double bond within either 9-membered ring (bicycle-[7.3.0]-dodecadienediyne) or 10-membered ring (bicycle-[7.3.1]-tridecadiynene). Despite their structu...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/53510 |