Characterization of molecular differences between WASP and N-WASP and characterization of mutations causing Wiskott-Aldrich syndrome
Wiskott-aldrich Syndrome is caused by mutation in gene encodes WASP. WASP and its homologue N-WASP regulate actin cytoskeleton reorganization, share more than 50% sequence identity. Knocking down of WASP expression impaired Jurkat T-cells chemotaxis towards SDF-1α and increased adhesion to fibronect...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/54852 |