Structural features that affect β2 integrin expression and regulation of adhesion
A hallmark for the Leukocyte Adhesion Deficiency 1 (LAD-1) syndrome is the defect in the β2 integrins due to mutations in the ITGB2 gene. To establish the correlation between LAD-1 genotype and phenotype, as well as better understand integrin function and structure, 19 LAD-1 missense mutants that re...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/55003 |