Nucleosomal DNA sequence-dependent properties, targeting by novel platinum-intercalator compounds, and interactions with the p53 transcription factor
DNA in the context of chromatin encodes the instructions for life, and in eukaryotic cells is packaged by histone proteins, together with other nuclear factors. The fundamental repeating unit of chromatin is the nucleosome, which packages DNA and regulates its accessibility by transacting factors. I...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | http://hdl.handle.net/10356/62215 |