The role of Mek/Erk signalling inhibition and Krüppel-like factor 2 in mouse ground state pluripotency
The maintenance of undifferentiated mouse embryonic stem cells (mESCs) requires the presence of LIF and serum. Interestingly, by using two chemical molecules to inhibit both the pro-differentiative Fgf/Mek/Erk and Gsk3/Tcf3 pathways in mESCs (dual inhibition or “2i”), a pluripotent “ground state”, r...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | https://hdl.handle.net/10356/62942 |