Eg5 and TPX2 in cohesion fatigue
The fidelity of chromosome segregation is ensured by organized cleavage of cohesin at the metaphase-to-anaphase transition. However, prolonged metaphase arrest by proteasomal inhibitor MG132 resulted in an asynchronous loss of sister chromatid cohesion, termed cohesion fatigue. Using immunofluoresce...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | http://hdl.handle.net/10356/65060 |