Stromal fibroblasts impaired in TGF-beta signaling prime the microenvironment with extracellular hydrogen peroxide and mitogenic factors to support the oncogenic transformation of adjacent epithelia
Epithelial cancers arise when the homeostatic interaction between epithelial cells and stromal fibroblasts is perturbed, and the fibroblasts can support the development of a tumor microenvironment by providing the necessary oncogenic signals. Transforming growth factor p (TGFp),...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | http://hdl.handle.net/10356/65128 |