The activation states of LFA-1 (alphaL beta2) and related integrins

The activation states of LFA-1 (alphaL beta2) and related integrins

Leukocyte integrins (beta2 integrins) are involved in many immune and inflammatory responses. The key function of leukocytes is impaired in the LAD-I patients due to the defects in beta2 gene. Two missense LAD-1 mutations N329S and R571C were studied. alphaLbeta2N329S can mediate constitutive adhesi...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Cheng, Ming
Awduron Eraill:	Alex Law Sai Kit
Fformat:	Traethawd Ymchwil
Cyhoeddwyd:	2008
Pynciau:	DRNTU::Science::Biological sciences::Molecular biology
Mynediad Ar-lein:	https://hdl.handle.net/10356/6577

Eitemau Tebyg

The activation states of LFA-1 (αLβ2) and related integrins
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Cyhoeddwyd: (2010)

The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1
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Characterization of kindlin3 in Integrin functions
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Structural features that affect β2 integrin expression and regulation of adhesion
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Structure-function analysis of ß2 integrins using monoclonal antibodies.
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ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters
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Characterization of single amino acid substitutions in the β2 integrin subunit of patients with leukocyte adhesion deficiency (LAD)-1
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Characterization of structures and interactions of beta 2 integrin tail with cytosolic proteins
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Beta 3 integrins : negative regulators of angiogenesis
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Structural and biochemical study of kindlin-3 in integrin activation
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Characterisation and functional study of activation function 1 (AF-1) of progesterone receptor in mouse model
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Characterization of novel neuroprotective ligands modulating molecular behavior of alpha synuclein in Parkinson's disease
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Talin and kindlin : batman and robin of Mac1 integrin activation?
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Positional information modulates transient regeneration-activated cell states during vertebrate appendage regeneration
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FYVE1/FREE1 is involved in glutamine-responsive TORC1 activation in plants
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Structural and functional characterization of integrin αLβ2
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Cyhoeddwyd: (2011)

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Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells
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Adaptor regulation of LFA-1 signaling in T lymphocyte migration : potential druggable targets for immunotherapies?
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Modulation of adult stem cell activity by microbial indole production in the host-microbiome interaction context
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Three disparate studies on the CD18 integrin : expression and biological functions of the human CD18 integrin in health and disease
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Effects of thrombin and its related peptide fragments on neutrophils
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Cyhoeddwyd: (2018)

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The effect of the amyloid-beta peptide on the fluidity of cell membranes : a study by fluorescence correlation spectroscopy
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Brain site-specific proteome changes in aging-related dementia
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Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fasted Caenorhabditis elegans
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Cyhoeddwyd: (2024-06-01)

Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1)
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Cyhoeddwyd: (2013)

The nuclear envelope protein – Sun1 : its role in mechanosignaling and cytoskeletal dynamics.
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Cyhoeddwyd: (2010)

The role of Mek/Erk signalling inhibition and Krüppel-like factor 2 in mouse ground state pluripotency
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Anticancer activities of novel hyper-charged antimicrobial peptides
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Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury
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