Fragment-based drug discovery and mechanistic studies of human thymidylate synthase
Human thymidylate synthase (hTS) is the sole enzyme responsible for de novo biosynthesis of dTMP and is vital to cell proliferation and survival. Inhibition of hTS has been explored and found to be effective in cancer chemotherapy, while the efficacy is limited by drug resistance. Herein fragment sc...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2016
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| Online Access: | https://hdl.handle.net/10356/65932 |