Computer modelling on human telomeric dna g-quadruplexes, from stability, folding dynamics to ligand binding
G-quadruplex is a non-canonical yet crucial secondary structure of nucleic acids, which has proven its importance in cell aging, anti-cancer therapies, gene expression and genome stability. In this PhD thesis, we studied the five established structural models of human telomeric DNA G-quadruplexes on...
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| Format: | Thesis |
| Language: | English |
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2016
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| Online Access: | http://hdl.handle.net/10356/68827 |