Role of glycosylation in EGFR ectodomain interactions : a molecular dynamics study
The Epidermal Growth Factor Receptor (EGFR) is a tyrosine kinase protein, overexpressed in several cancers. The extracellular domain of EGFR is heavily glycosylated with sugar moieties of varying compositions. Growth factor (mostly Epidermal Growth Factor or EGF) binding activates EGFR. This occurs...
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| Format: | Thesis |
| Language: | English |
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2017
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| Online Access: | http://hdl.handle.net/10356/71976 |