Modelling Mitchell-Riley Syndrome in vitro using iPS cells derived from RFX6 mutant patient

The forkhead transcription factor Regulatory Factor X, 6 (RFX6) is essential for the development of the mammalian pancreas. In humans, RFX6 mutations are responsible for Mitchell-Riley Syndrome (MRS), which is characterized by neonatal diabetes with pancreatic hypoplasia. Similarly, Rfx6 mutant mice...

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Détails bibliographiques
Auteur principal: Alpagu, Yunus
Autres auteurs: Ray Dunn
Format: Thèse
Langue:English
Publié: 2018
Sujets:
Accès en ligne:http://hdl.handle.net/10356/75844