Effect of CRISPR-based epigenetic interference on cis-regulatory gene networks
The revolutionary CRISPR-Cas9 genome engineering technology has been repurposed into a docking tool by fusing various effector proteins to the catalytically inactive Cas9. The modified system can regulate transcription by editing the epigenetic code, thereby modifying the local chromatin structure....
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/80404 http://hdl.handle.net/10220/46576 |