Mussel-Inspired Modification of Nanofibers for REST siRNA Delivery: Understanding the Effects of Gene-Silencing and Substrate Topography on Human Mesenchymal Stem Cell Neuronal Commitment

Mussel-Inspired Modification of Nanofibers for REST siRNA Delivery: Understanding the Effects of Gene-Silencing and Substrate Topography on Human Mesenchymal Stem Cell Neuronal Commitment

In this study, we promote neuronal differentiation of human mesenchymal stem cells (MSCs) through scaffold-mediated sustained release of siRNA targeting RE-1 silencing transcription factor (REST). Poly (ϵ-caprolactone) nanofibers were surface modified with mussel inspired DOPA-melanin (DM) coating f...

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Bibliographic Details
Main Authors: Low, Wei Ching, Rujitanaroj, Pim-On, Lee, Dong-Keun, Kuang, Jinghao, Messersmith, Phillip B., Chan, Jerry Kok Yen, Chew, Sing Yian
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2015
Subjects:
Electrospinning
Neuronal differentiation
RE-1 silencing transcription factor
Sustained release
Neural differentiation
Online Access:https://hdl.handle.net/10356/80820
http://hdl.handle.net/10220/38902

Internet

https://hdl.handle.net/10356/80820
http://hdl.handle.net/10220/38902

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