Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

Exogenous RNAi triggers such as shRNAs ideally exert their activities exclusively via the antisense strand that binds and silences designated target mRNAs. However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including off-target...

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Bibliographic Details
Main Authors: Mockenhaupt, Stefan, Grosse, Stefanie, Rupp, Daniel, Bartenschlager, Ralf, Grimm, Dirk
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2015
Subjects:
Adeno-associated viral vector
AAV
RNA interference
Short hairpin RNA
Off-targeting
Online Access:https://hdl.handle.net/10356/81167
http://hdl.handle.net/10220/39147

Internet

https://hdl.handle.net/10356/81167
http://hdl.handle.net/10220/39147

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