Toward stable gene expression in CHO cells Preventing promoter silencing with core CpG island elements

Maintaining high gene expression level during long-term culture is critical when producing therapeutic recombinant proteins using mammalian cells. Transcriptional silencing of promoters, most likely due to epigenetic events such as DNA methylation and histone modifications, is one of the major mecha...

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Dettagli Bibliografici
Autori principali: Mariati, Koh, Esther YC, Yeo, Jessna HM, Ho, Steven CL, Yang, Yuansheng
Altri autori: School of Chemical and Biomedical Engineering
Natura: Journal Article
Lingua:English
Pubblicazione: 2016
Soggetti:
Accesso online:https://hdl.handle.net/10356/81451
http://hdl.handle.net/10220/40784