Toward stable gene expression in CHO cells Preventing promoter silencing with core CpG island elements

Toward stable gene expression in CHO cells Preventing promoter silencing with core CpG island elements

Maintaining high gene expression level during long-term culture is critical when producing therapeutic recombinant proteins using mammalian cells. Transcriptional silencing of promoters, most likely due to epigenetic events such as DNA methylation and histone modifications, is one of the major mecha...

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Bibliographic Details
Main Authors: Mariati, Koh, Esther YC, Yeo, Jessna HM, Ho, Steven CL, Yang, Yuansheng
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2016
Subjects:
CHO
core CpG island element
gene silencing
expression stability
Online Access:https://hdl.handle.net/10356/81451
http://hdl.handle.net/10220/40784

Internet

https://hdl.handle.net/10356/81451
http://hdl.handle.net/10220/40784

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