Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

The therapeutic use of VEGF165 to stimulate blood vessel formation for the treatment of peripheral arterial disease or cardiovascular-related disease has met with limited success. Here we describe an affinity-isolated heparan sulfate glycotherapeutic (HS7+ve) that binds to, and enhances the bioactiv...

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Bibliographic Details
Main Authors: Wang, Chunming, Poon, Selina, Murali, Sadasivam, Koo, Chuay-Yeng, Bell, Tracey J., Hinkley, Simon F., Yeong, Huiqing, Bhakoo, Kishore, Nurcombe, Victor, Cool, Simon M.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2016
Subjects:
Angiogenesis
Vasculogenesis
Online Access:https://hdl.handle.net/10356/81666
http://hdl.handle.net/10220/40874

Internet

https://hdl.handle.net/10356/81666
http://hdl.handle.net/10220/40874

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