Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy
The therapeutic use of VEGF165 to stimulate blood vessel formation for the treatment of peripheral arterial disease or cardiovascular-related disease has met with limited success. Here we describe an affinity-isolated heparan sulfate glycotherapeutic (HS7+ve) that binds to, and enhances the bioactiv...
Main Authors: | Wang, Chunming, Poon, Selina, Murali, Sadasivam, Koo, Chuay-Yeng, Bell, Tracey J., Hinkley, Simon F., Yeong, Huiqing, Bhakoo, Kishore, Nurcombe, Victor, Cool, Simon M. |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/81666 http://hdl.handle.net/10220/40874 |
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