Functionalised staple linkages for modulating the cellular activity of stapled peptides

Functionalised staple linkages for modulating the cellular activity of stapled peptides

Stapled peptides are a promising class of alpha-helix mimetic inhibitors for protein–protein interactions. We report the divergent synthesis of “functionalised” stapled peptides via an efficient two-component strategy. Starting from a single unprotected diazido peptide, dialkynyl staple linkers bear...

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Bibliographic Details
Main Authors: Lau, Yu Heng, de Andrade, Peterson, Quah, Soo-Tng, Rossmann, Maxim, Laraia, Luca, Sköld, Niklas, Sum, Tze Jing, Rowling, Pamela J. E., Joseph, Thomas L., Verma, Chandra, Hyvönen, Marko, Itzhaki, Laura S., Venkitaraman, Ashok R., Brown, Christopher J., Lane, David P., Spring, David R.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2016
Subjects:
Cell permeability
Biomimetics
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/81934
http://hdl.handle.net/10220/41069

Internet

https://hdl.handle.net/10356/81934
http://hdl.handle.net/10220/41069

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