The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

The extant jawless vertebrates, represented by lampreys and hagfish, are the oldest group of vertebrates and provide an interesting genomic evolutionary pivot point between invertebrates and jawed vertebrates. Through genome analysis of one of these jawless vertebrates, the Japanese lamprey (Lethent...

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Bibliographic Details
Main Authors: Venkatesh, Byrappa, Lane, David P., Coffill, Cynthia R., Lee, Alison P., Siau, Jia Wei, Chee, Sharon M., Joseph, Thomas L., Tan, Yaw Sing, Madhumalar, Arumugam, Tay, Boon-Hui, Brenner, Sydney, Verma, Chandra Shekhar, Ghadessy, Farid J.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2016
Subjects:
P53
Mdm2
Mdm4
Evolution
Lamprey
Online Access:https://hdl.handle.net/10356/82782
http://hdl.handle.net/10220/40297

Internet

https://hdl.handle.net/10356/82782
http://hdl.handle.net/10220/40297

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