Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Dengue virus (DENV) causes several hundred million human infections and more than 20,000 deaths annually. Neither an efficacious vaccine conferring immunity against all four circulating serotypes nor specific drugs are currently available to treat this emerging global disease. Capping of the DENV RN...

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Bibliographic Details
Main Authors: Zhao, Yongqian, Soh, Tingjin Sherryl, Lim, Siew Pheng, Chung, Ka Yan, Swaminathan, Kunchithapadam, Vasudevan, Subhash G., Shi, Pei-Yong, Lescar, Julien, Luo, Dahai
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2016
Subjects:
2′-O-ribose methyltransferase
Dengue virus
Nonstructural protein 5 methyltransferase-polymerase
Cap-0 RNA
Innate immunity evasion
Online Access:https://hdl.handle.net/10356/82917
http://hdl.handle.net/10220/40374

Internet

https://hdl.handle.net/10356/82917
http://hdl.handle.net/10220/40374

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