Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism

Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism

Effective control of endotoxins and bacteria is crucial for normal wound healing. During injury, the key enzyme thrombin is formed, leading to generation of fibrin. Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa thrombin-derived C-terminal peptides (TCPs), which bin...

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Bibliographic Details
Main Authors: Petrlova, Jitka, Hansen, Finja C., van der Plas, Mariena J. A., Huber, Roland G., Mörgelin, Matthias, Malmsten, Martin, Bond, Peter J., Schmidtchen, Artur
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2017
Subjects:
Aggregation
Host defense peptides
Online Access:https://hdl.handle.net/10356/83618
http://hdl.handle.net/10220/42778

Internet

https://hdl.handle.net/10356/83618
http://hdl.handle.net/10220/42778

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