mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

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MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at steady state in the few contexts examined globally. Here, we extend the global steady-state measurements to additional mammalian contexts and f...

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Detalhes bibliográficos
Principais autores: Eichhorn, Stephen W., Guo, Huili, McGeary, Sean E., Rodriguez-Mias, Ricard A., Shin, Chanseok, Baek, Daehyun, Hsu, Shu-hao, Ghoshal, Kalpana, Villén, Judit, Bartel, David P.
Outros Autores: Lee Kong Chian School of Medicine (LKCMedicine)
Formato: Journal Article
Idioma:English
Publicado em: 2016
Assuntos:
RNA degradation
microRNA
Acesso em linha:https://hdl.handle.net/10356/83818
http://hdl.handle.net/10220/41504

Internet

https://hdl.handle.net/10356/83818
http://hdl.handle.net/10220/41504

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