mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at steady state in the few contexts examined globally. Here, we extend the global steady-state measurements to additional mammalian contexts and f...

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Bibliographic Details
Main Authors: Eichhorn, Stephen W., Guo, Huili, McGeary, Sean E., Rodriguez-Mias, Ricard A., Shin, Chanseok, Baek, Daehyun, Hsu, Shu-hao, Ghoshal, Kalpana, Villén, Judit, Bartel, David P.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2016
Subjects:
RNA degradation
microRNA
Online Access:https://hdl.handle.net/10356/83818
http://hdl.handle.net/10220/41504

Internet

https://hdl.handle.net/10356/83818
http://hdl.handle.net/10220/41504

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