Modulating release of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization

Modulating release of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization

Background: This paper describes the synthesis of thiolated chitosan-based hydrogels with varying degrees of crosslinking that has been utilized to modulate release kinetics of two clinically relevant FDA-approved anti-VEGF protein drugs, ranibizumab and aflibercept. These hydrogels have been fabric...

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Bibliographic Details
Main Authors: Moreno, Miguel, Pow, Poh Yih, Tan, Su Teng Tabitha, Nirmal, Sonali, Larsson, Andreas, Radhakrishnan, Krishna, Nirmal, Jayabalan, Quah, Soo Tng, Shochat, Susana Geifman, Agrawal, Rupesh, Venkatraman, Subbu S.
Other Authors: School of Materials Science & Engineering
Format: Journal Article
Language:English
Published: 2017
Subjects:
Thiolated chitosan-based hydrogels
Anti-vascular endothelial growth factor proteins
Online Access:https://hdl.handle.net/10356/84063
http://hdl.handle.net/10220/42956

Internet

https://hdl.handle.net/10356/84063
http://hdl.handle.net/10220/42956

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