Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

The recent discovery of small molecules targeting the cytochrome bc 1 : aa 3 in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome bc 1 : aa 3 consists of a menaquinone:cytochrome c reductase ( bc 1 )...

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Bibliographic Details
Main Authors: Hasenoehrl, Erik J., Koh, Vanessa H., Ang, Michelle L. T., Sajorda, Dannah R., Hards, Kiel, Grüber, Gerhard, Alonso, Sylvie, Cook, Gregory M., Berney, Michael, Pethe, Kevin, Kalia, Nitin Pal, Ab Rahman, Nurlilah Binte
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2017
Subjects:
Bioenergetics
Oxidative Phosphorylation
Online Access:https://hdl.handle.net/10356/84353
http://hdl.handle.net/10220/43577

Internet

https://hdl.handle.net/10356/84353
http://hdl.handle.net/10220/43577

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