Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

Dissecting the complexities of branched peptide-lipopolysaccharides (LPS) interactions provide rationale for the development of non-cytotoxic antibiotic adjuvants. Using various biophysical methods, we show that the branched peptide, B2088, binds to lipid A and disrupts the supramolecular organizati...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Lakshminarayanan, Rajamani, Tan, Wei Xiang, Aung, Thet Tun, Goh, Eunice Tze Leng, Muruganantham, Nandhakumar, Li, Jianguo, Chang, Jamie Ya Ting, Dikshit, Neha, Saraswathi, Padmanabhan, Lim, Rayne Rui, Kang, Tse Siang, Balamuralidhar, Vanniarajan, Sukumaran, Bindu, Verma, Chandra S., Sivaraman, Jayaraman, Chaurasia, Shyam Sunder, Liu, Shouping, Beuerman, Roger W.
Бусад зохиолчид: School of Biological Sciences
Формат: Journal Article
Хэл сонгох:English
Хэвлэсэн: 2016
Нөхцлүүд:
Antibiotics
Bacterial infection
Онлайн хандалт:https://hdl.handle.net/10356/84726
http://hdl.handle.net/10220/41946

Интернэт

https://hdl.handle.net/10356/84726
http://hdl.handle.net/10220/41946

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