Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-qu...

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Bibliographic Details
Main Authors: Chambers, Vicki S., Di Antonio, Marco, Sengar, Anjali, Balasubramanian, Shankar, Phan, Anh Tuân, Winnerdy, Fernaldo Richtia, Vandana, J. Jeya
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2019
Subjects:
G-quadruplex
PARP1 Promoter
Science::Chemistry
Online Access:https://hdl.handle.net/10356/86025
http://hdl.handle.net/10220/49248

Internet

https://hdl.handle.net/10356/86025
http://hdl.handle.net/10220/49248

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