Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Carboxylic acids are common moieties in medicines. They can be converted to phthalidyl esters as prodrugs. Unfortunately, phthalidyl esters are now mostly prepared in racemic forms. This is not desirable because the two enantiomers of phthalidyl esters likely have different pharmacological effects....

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Bibliographic Details
Main Authors: Liu, Yingguo, Chen, Qiao, Mou, Chengli, Pan, Lutai, Duan, Xiaoyong, Chen, Xingkuan, Chen, Hongzhong, Zhao, Yanli, Lu, Yunpeng, Jin, Zhichao, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2019
Subjects:
Asymmetric Catalysis
Drug Discovery and Development
Science::Chemistry
Online Access:https://hdl.handle.net/10356/87107
http://hdl.handle.net/10220/49866

Internet

https://hdl.handle.net/10356/87107
http://hdl.handle.net/10220/49866

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