Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration

Oxidative and endoplasmic reticulum (ER) stresses are hallmarks of the pathophysiology of ALS and other neurodegenerative diseases. In these stresses, different kinases phosphorylate eukaryotic initiation factor eIF2α, enabling the translation of stress response genes; among these is GADD34, the pro...

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Bibliographic Details
Main Authors: Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2018
Subjects:
Phosphoprotein Phosphatase 1 (PP1)
Oxidative Stress
Online Access:https://hdl.handle.net/10356/87420
http://hdl.handle.net/10220/44400

Internet

https://hdl.handle.net/10356/87420
http://hdl.handle.net/10220/44400

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