Calcineurin B in CD4+ T cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway

Calcineurin B in CD4+ T cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway

Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically del...

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Bibliographic Details
Main Authors: Mencarelli, Andrea, Vacca, Maurizio, Khameneh, Hanif Javanmard, Acerbi, Enzo, Tay, Alicia, Zolezzi, Francesca, Poidinger, Michael, Mortellaro, Alessandra
Other Authors: Singapore Centre for Environmental Life Sciences Engineering
Format: Journal Article
Language:English
Published: 2018
Subjects:
Calcineurin B
Nuclear Factor of Activated T Cell
Online Access:https://hdl.handle.net/10356/87680
http://hdl.handle.net/10220/45534

Internet

https://hdl.handle.net/10356/87680
http://hdl.handle.net/10220/45534

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