Calcineurin B in CD4+ T cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway
Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically del...
Main Authors: | Mencarelli, Andrea, Vacca, Maurizio, Khameneh, Hanif Javanmard, Acerbi, Enzo, Tay, Alicia, Zolezzi, Francesca, Poidinger, Michael, Mortellaro, Alessandra |
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Other Authors: | Singapore Centre for Environmental Life Sciences Engineering |
Format: | Journal Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/87680 http://hdl.handle.net/10220/45534 |
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